Serum cholesterol levels in anorexia nervosa.
نویسندگان
چکیده
IN CONTRAST to earlier investigators (Pardee, 1941; Stephens, 1941; Emmanuel, 1956) more recent workers (Crisp, 1965a, 1967; Oberdisse, Solbach & Zimmerman, 1965; Klinefelter, 1965; Crisp & Stonehill, 1967) have reported that some of their patients with anorexia nervosa have high serum cholesterol levels. Crisp (1965a, b, 1967) in a study of eighty patients (Nos. 1-80) has also emphasized that anorexia nervosa is predominantly a state of severe chronic carbohydrate starvation having its origins in the patient's phobia of and consequent need to avoid normal adolescent weight. Such patients who will have initially turned to eating supposedly 'non-fattening' foods such as as cheese, fruit, meat and salad, may later surrender to their increasing impulse to eat carbohydrate by having binges. They may start to vomit in relation to their binges and conceal and deny one or both these aspects. Usually such binges also alternate with phases when the patient stops eating altogether. Such cycles may recur every 24 hr or may span several weeks. These complex and often interrelating patterns of feeding make it more than usually difficult to assess the past dietary intake. Meanwhile, a further study by Crisp et al. (1967) has confirmed that thirty-seven female patients aged 14-33 with anorexia nervosa had significantly higher serum cholesterol levels (P<0 0002) than thirty-seven normal women with whom they were matched individually for age (Fig. 1). The serum cholesterol levels in the control group are the mean of two results from the two halves of the menstrual cycle. However, there was a wide variation of serum cholesterol levels amongst the anorexia nervosa group. It was confirmed that such levels bore no relationship to thyroid function or reduced plasma volume and were unlikely to be due to diminished oestrogen activity, a universal characteristic in
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ورودعنوان ژورنال:
- Postgraduate medical journal
دوره 44 510 شماره
صفحات -
تاریخ انتشار 1968